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For microbiome changes, alterations in bacterial makeup may be detectable within 2-4 weeks of treatment, though major shifts in microbiome diversity and function may need 8-12 weeks or longer

Gastrointestinal side effects from B12 supplements are typically mild, transient, and often related to inactive ingredients rather than the vitamin itself

Glutathione shifts the process of melanogenesis from eumelanin to pheomelanin through the reaction between thiol and dopaquinone groups causing formation of sulfhydryl-dopa conjugates[] [Figure 2]